I am passing along this email for a couple of reasons. I am all for getting our government back to serving our needs, instead of theirs. Congress giving themselves raises in bad times, just because they can, doesn’t work for me. I like what Warren Buffett is proposing. I hope you will also pass this along.
The BUFFETT Rule
Let’s see what people-pressure is all about.
Salary of retired US Presidents = $180,000 FOR LIFE.
Salary of House/Senate members = $174,000 FOR LIFE.
Salary of Speaker of the House = $223,500 FOR LIFE.
Salary of Majority / Minority Leaders = $193,400 FOR LIFE.
Average Salary of a teacher = $40,065
Average Salary of a deployed Soldier = $38,000
Here’s where the cuts should be made!
Warren Buffett, in a recent interview with CNBC, offers one of the best quotes about the debt ceiling:
“I could end the deficit in five minutes,” he told CNBC. “You just pass a law that says that anytime there is a deficit of more than 3% of GDP, all sitting members of Congress are ineligible for re-election.”
The 26th Amendment (granting the right to vote for 18 year-olds) took only three months and eight days to be ratified! Why? Simple! The people demanded it. That was in 1971 – before computers, e-mail, cell phones, etc.
Of the 27 amendments to the Constitution, seven (7) took one (1) year or less to become the law of the and – all because of public pressure.
Warren Buffett is asking each addressee to forward this email to a minimum of twenty people on their address list; in turn ask each of those to do likewise.
In three days, most people in The United States of America will have the message. This is one idea that really should be passed around.
Congressional Reform Act of 2022
1. No Tenure / No Pension. A Congressman / woman collects a salary while in office and receives no pay when they’re out of office.
2. Congress (past, present, & future) participates in Social Security.
All funds in the Congressional retirement fund move to the Social Security system immediately. All future funds flow into the Social Security system, and Congress participates with the American people. It may not be used for any other purpose.
3. Congress can purchase their own retirement plan, just as all Americans do.
4. Congress will no longer vote themselves a pay raise. Congressional pay will rise by the lower of CPI or 3%.
5. Congress loses their current health care system and participates in the same health care system as the American people.
6. Congress must equally abide by all laws they impose on the American people.
7. All contracts with past and present Congressmen/women are void effective 3/1/22. The American people did not make this contract with Congressmen/women. Congress made all these contracts for themselves. Serving in Congress is an honor, not a career. The Founding Fathers envisioned citizen legislators, so ours should serve their term(s), then go home and go back to work.
If each person contacts a minimum of twenty people, then it will only take three days for most people in the U.S. to receive the message. It’s time!
This is really a great article because aside from Hydrogen Peroxide & Nebulizers, He mentions the importance of Iodine and other items that have always been on my protocol.
Most of you know my protocol for maintaining or creating a strong immune system. There are dozens of other products out there–my policy is to recommend the very best product at an affordable cost that I can guarantee will work. The protocols are as follows Supplements Beta 1,3 D Glucan (1) daily Astaxanthin (1) daily Vitamin D (1) daily Ormed Vitamin C (5 drops (1x daily) Detoxified Iodine Drops (6 drops 1-2 daily)N Acetyl Cysteine NAC (1 cap or tab 1-2 x daily) LUNGS Techniques Dr. P’s Humidifier Technique (Physicians Strength Oregano, Peroxide, Silver 500, Distilled Water) Nebulizer Hydrogen Peroxide (Food Grade Hydrogen Peroxide diluted down to 1-4% strength) Nebulizer Mild Silver Protein 500
**A reminder that 80% of our immune system is based in our Gut
Nothing says “Summer” better than a cool, refreshing, sweet, juicy, delicious slice of ripe watermelon—no matter what time of year it is. But I often hear cautions on eating watermelon—that it is high glycemic, full of sugar, mostly water, not very nutritious, etc.
NOTE: While watermelon does contain fruit sugar —fructose — like all other fruits, it is nearly 92 percent water. Just because it tastes sweet does not make it high in sugar. … This term, called glycemic load, is very low for watermelon — meaning that blood sugar is not changing much after eating it-but for diabetics, don’t overdo it!
Right? Or wrong?
While watermelons are mostly water—90% or so, they are also full of vitamins A, B6, C, lycopene, antioxidants and minerals. Remember hearing about the lycopene in tomatoes? Watermelon, another red-colored fruit, is FULL of this powerful phytonutrient! In fact, watermelon has some of the highest levels of lycopene of all fruits and veggies. Just one cup of watermelon has 1 and a half times the lycopene of a large fresh tomato. And who eats just one cup of watermelon? I know I don’t!
Because watermelon is one of the best sources of lycopene with more than 6,500 micrograms in less than half a cup, you are getting an army’s worth of inflammation-fighting antioxidant activity! Lycopene from the red flesh of watermelon is very stable, even after the watermelon has been cut and stored in the refrigerator. Lycopene is thought to be even more powerful than its other orange/red colored ally, beta carotene—found in red and orange fruits and veggies.
Lycopene is a powerful natural anti-inflammatory and antioxidant, valued for its role in protecting the cardiovascular system, bone health, and preventing cancer. Along with lycopene, watermelons contain another powerful phytochemical, citrulline, an amino acid. Citrulline gets converted into another important chemical in the body, arginine, or L-arginine. Arginine is used to create nitric oxide, which has powerful benefits on the heart and blood vessels. NO can actually cause blood vessels to relax and open up, lowering blood pressure and helping the body carry more oxygen to parts of the body where it is needed–like muscles, your heart and your brain. A study from Florida State University found that watermelon could make a significant difference in lowering blood pressure–especially in overweight people, by relaxing the blood vessel walls.
Citrulline, when it converts into arginine, can also help prevent excess accumulation of fat in fat cells, because it blocks an enzyme that stores this fat. And because citrulline is a precursor to nitric oxide, it can also help improve erectile dysfunction in men, in a similar way that Viagra works—although you would have to quite a bit of watermelon to get the same effect as Viagra.
Carotenoids are powerful antioxidants, capable of destroying free radicals which attack our bodies and can contribute to chronic disease and aging. In one study of 13,000 adult Americans, low levels of carotenoids were a key predictor of early death. Especially low blood levels of lycopene! Lycopene protects our cardiovascular system, the male reproductive system, and in the skin, it protects and prevents UV damage from the sun.
Several studies have been conducted showing the strong link between levels of lycopene and heart disease. Analyses from the Physicians Health Study showed a 39% decrease in stroke risk in men with the highest blood levels of lycopene. Another study in Finland following 1,000 men for 12 years has had similar results as well.
Lycopene is also responsible for limiting the enzyme responsible for making cholesterol, so eating foods with more lycopene also helps to reduce cholesterol—specifically, LDL cholesterol.
Lycopene is a life-saver in more ways than one! Besides its cardiovascular benefits, lycopene’s antioxidant power extends to anti-cancer effects as well. A 2014 meta-analysis of 10 studies shows dietary lycopene to be protective against ovarian cancers, as well as brain tumors and breast tumors.
And of course, we know about lycopene’s value in fighting prostate cancer. In several studies, higher intakes of foods containing lycopene and a higher serum or plasma concentration of lycopene was associated with a very significant decreased risk of prostate cancer—especially the more lethal kind of prostate cancer. When researchers studied only the men who had had at least one high risk PSA test, the subjects had a 50% decreased risk of lethal prostate cancer.
“Based on these results, we hypothesize that the consumption of a diet rich in lycopene-containing foods reduces the aggressive potential of prostate cancer by inhibiting the neoangiogenesis that occurs in tumor development,” Dr. Giovannucci’s team reported online ahead of print in the Journal of the National Cancer Institute.”
Other studies have shown lycopene’s powerful cancer fighting ability effective against lung cancer, esophageal, stomach, pancreatic, colorectal, and cervical cancers as well.
Extremely Good for Rehydration
Watermelons get their name because they are over 90% water, and that water is full of electrolytes and potassium which helps you stay hydrated or to rehydrate. The perfect fruit to eat on hot summer days, or after a hard, sweaty workout! And that delicious juice can also help prevent muscle soreness—especially if you have watermelon before your intense workout.
It’s Not Just the Red Part
While most of us only eat the juicy red flesh of the watermelon, the whole thing is actually edible and chock full of nutrients! From the red center to the stem end, and also the blossom end–including the white part near the rind–are a plethora of impressive antioxidants, flavonoids, lycopene, and vitamin C. Even the green rind is full of nutrients. The rind is full of chlorophyll, and contains even more citrulline than the red flesh. Try throwing your watermelon rinds into the blender with fresh squeezed lime juice for a healthy slushy treat.
It is still best, however, to pick ripest, reddest watermelon you can find. Lycopene content continues to increase all the way up until the time the watermelon is at its reddest and ripest.
And don’t spit out those seeds, unless you are in a watermelon seed-spitting contest! The black watermelon seeds are not only edible, but actually extremely good for you. They are full of iron, zinc, fiber and protein. Seedless watermelons are ok to eat too—they are not genetically modified, only hybrid forms of watermelon bred especially for their no-seed content.
Watermelons also are rich in anti-inflammatory substances including cucurbitacin E, triterpenoid which help to block the pain and inflammation of certain enzymes, in a similar fashion as NSAID’s like ibuprofen and aspirin.
While being very low in calories (only about 46 calories in a cup), watermelon also contains an impressive variety of other important essential nutrients including:
The Age-Old Question—How Do You Pick the Perfect Watermelon?
It can be a huge gamble finding the perfect, red, sweet watermelon. But—if you know what to look for, there is a real method to finding the best one. Look on the underside of the watermelon for a pale, butter-colored yellow spot—not white or green. This is one of the best indicators of the ripeness of the watermelon. Also pick up a few and choose the one that is heaviest for its size. Many people ‘thump’ the watermelon to check its ripeness too—listen for the best hollow bass sound.
Be aware that watermelons do contain a reasonable quantity of fructose, so be mindful of your sugar intake, and eat watermelon in moderation. With that said, because watermelons are so filling, and have both high water content AND high fiber content, the old myth that watermelons are high glycemic is not entirely true… This is because the “glycemic load” of a watermelon is actually fairly low since it’s nearly impossible to overeat large quantities of a food that is as filling as watermelon
Proof is in Bible Quotes—Positive Affirmations of Faith
“All things are possible to him that believeth.” (Mark 9:23)
“Be not faithless, but believing” (John 20:27)
“And these signs shall accompany them that believe; in My name shall they cast out demons; they shall lay hands on the sick and they shall recover.” (Mark 16:17, 18)
I believe; help Thou, my unbelief” Mark (9:24)
“Yes, Source and Maker, I believe You can and will heal any person upon whom I lay my hands”
Sick folks have faith and plenty of it—but in the wrong way. Your attention is your faith. Whatever gets your attention, you have faith in. Whatever you expect and prepare for, you have faith in.
Some facts about Faith:
Words of faith can be creating, or dissolving, according to whatever one has faith in.
The power of faith has equal authority to destroy one’s health, if used destructively as do words of faith that create a and build up one’s health
A person who is sick and attending a healing circle to receive healing prayers will get not better if he keeps talking about his ill health and listens to descriptions of ill health problems enjoyed” by a neurotic neighbor. Through that person’s faith and attention to ill health, he keeps it manifesting. His faith is indeed an irrepressible force, but for illness instead of wholeness.
is more than a positive personality trait or a willy-nilly feeling.
Gratitude has the power to change the lens through which we view the
world, bringing us more joy, health and satisfaction. It’s easy to see
the problems in life, not because we are cynical, but because we are
looking for what we can improve in our lives. The downside to this is
that we can skip over the miracles in our lives, taking the small gifts
Creating a gratitude practice such as a
gratitude jar, gratitude meditation or a gratitude journal is a great
way to press pause on that dissatisfied inner voice constantly seeking
The Definition of Gratitude
The word gratitude is derived from the Latin
word gratia, which translates as grace or favor. Interestingly, the
word grace is defined as “smoothness and elegance of movement” and
“courteous goodwill,” which speaks of bringing flow and harmony into
Another phrase for gratia in Latin is “gratus animus.” Gratus means grateful, agreeable, pleasing, acceptable and welcome. Animus means
heart, mind, affections, purpose and feeling. Much of human life is
about kindness and compassion (giving and receiving), which makes a
gratitude practice so transformative.
Recognizing and affirming benevolence has a vitalizing effect on the mind, body and spirit. That might be why gratitude is at the core of every major spiritual tradition.
The roots of a gratitude practice must be in selflessly rejoicing in
the other and seeking opportunities for giving, rather than using it as a
narcissistic self-improvement technique.
A practice of gratitude will help you to
live a wonderful life, and is the opposite of being entitled. Rather, a
practice of gratitude is rejoicing in the gifts and wonders of life.
Gratitude has been established as a universal human attribute suggesting
that it is at the core of our very being.
The Healing Power of Gratitude
Gratitude has amazing powers of improving mental health
and has proven in clinical trials to have long lasting healing
properties. It promotes feelings of love and tenderness toward other
people and life experiences. A deep practice of gratitude also has the
power of alleviating trauma, due to its other-directed understanding.
Gratitude is used in a clinical setting with Accelerated Experiential Dynamic Therapy (ADEPT).
ADEPT was designed by American psychologist Diana Fosha. The premise is
that we are all capable of self-healing and transformation in the right
environment. ADEPT is designed to create a deep emotional connection
with both yourself and other people.
“Be content with what you have; rejoice in
the way things are. When you realize there is nothing lacking, the whole
world belongs to you.” —Lao Tzu
In the paper Gratitude as a Psychotherapeutic Intervention
published by Yale Center for Emotional Intelligence and the University
of California, the writers astutely wrote: “Losing some aspects of one’s
life may lead the person to increase the value they see in other
aspects of life.”
Gratitude Breeds Connection
We all know that it’s nice to get gifts, but
the feeling of joy from material objects is fleeting. Taking the time
to be truly thankful for all of the blessings in your life will open
doors. Our life depends on the existence of everything in the universe,
from the sun and moon to the oceans and trees. And each person can play a
special role in our lives. Taking the time to write a thank you note to
spread the love has also been shown to benefit those with mental health
“With this attitude, people recognize that
they are connected to each other in a mysterious and miraculous way that
is not fully determined by physical forces, but is part of a wider, or
transcendent context.” -Streng (1989)
Gratitude can be seen as the elemental life
force that powers compassion. We are all intricately connected and as
such a practice of gratitude gives thanks to the interdependence,
interpenetration, and mutuality of living.
Gratitude isn’t merely positive thinking; it
is a deep appreciation for life. Contrast can also be viewed through
the eyes of gratitude. Pain and affliction can be released when they are
contrasted with more positive aspects of the now. No matter how small,
there is always something to be grateful for.
What does a Gratitude Practice Look Like?
In the first instance you can simply pay
attention to what is going well in your life. Taking time to shift your
focus from the negative to the positive. A gratitude practice should
include the understanding that even painful situations are teachers. The
simple act of redirecting our focus can take us from a place of
victimhood to appreciation, altering our view of the world.
Simple 3-Step Gratitude Practice
Step 1 – Attention – become aware of the blessings in your life that you may have taken for granted.
Step 2 – Tune into the many reasons for gratitude that exist in our lives.
Step 3 – Write it down – Writing is scientifically proven to
be more powerful than simply thinking thoughts of gratitude. You can
choose to write down one thought a day and place it in a gratitude jar.
Or you may like to keep a special gratitude journal and write down 5-10
blessings every day.
If you choose to use a gratitude jar, you
can amplify the benefits by sharing the experience with your family.
Sharing a gratitude jar will encourage family members to have a grateful
outlook on life. Counteracting feelings of entitlement, envy, and
resentment, which are negative feelings that push people away from us.
A gratitude jar encourages each member of the family to practice
thinking in a positive way that will bring joy, prosperity and
connection into your home.
“Always be rejoicing. Give thanks for everything.” -1 Thessalonians 5:16, 18.
Gratitude intervention remains an untapped
therapeutic resource that can be used by anyone, especially those
working in healthcare settings. Changing the perspective of a patient
from one of despair to gratitude could catalyze their healing process.
Adding gratitude techniques is an easy way to boost your self esteem and
that of those around you.
In 2002 several large-scale clinical studies
were published on the risks of breast cancer in postmenopausal women
using conventional FDA-approved hormone therapy. These were the Women’s
Health Initiative (WHI) and Million Women’s studies of women using
FDA-approved estrogens and progestogens in the United States and Great
Britain, respectively [1,2].
Both studies came to the same conclusion – that estrogen therapy,
mostly in the form of oral conjugated equine estrogens, by itself did
not significantly increase the risk of breast cancer and, to the
surprise of many, was associated with a lower risk. However, when
estrogen was combined with a synthetic progestin to prevent uterine
cancer, the breast cancer risk increased 1.5 to 2-fold. Virtually all
forms, of which there are many, of synthetic progestins increased risk
to about the same extent. Smaller studies suggested that FDA-approved
oral progesterone, which was not as widely used, did not increase risk
in combination with estrogen therapy. These results led to widescale
panic among postmenopausal women using conventional estrogen and
progestogen (both synthetic progestins and natural progesterone)
therapies and a precipitous drop in prescriptions for these forms of HRT
Many women stopped cold turkey all forms of hormone replacement therapy
(HRT), which significantly diminished their quality of life. Adverse
estrogen deficiency symptoms that were effectively suppressed with
estrogen therapy (e.g., hot flashes and night sweats, sleep
disturbances, memory issues, incontinence, vaginal dryness, depression,
weight gain, etc.) resurfaced with a vengeance in many women, as did
risk for diseases of advanced aging (e.g., bone loss and osteoporosis,
cardiovascular disease, stroke, diabetes, senile dementia, Alzheimer’s
disease). Women were left frightened between “damned if you do and
damned if you don’t,” and a large majority chose not to continue HRT.
Many health care providers refused to prescribe hormone therapy until
more information about risks were made available through clinical
Natural Progesterone Reduces Breast Cancer Risk
It was clear to me from the research literature
and smaller clinical studies that the natural hormone progesterone, when
delivered topically at a physiological dose (25 mg) protects normal
breast tissue from the growth promoting actions of estrogens.
When these and other studies emerged in 2002 John Lee, MD, and I
along with Virginia Hopkins had just published our book entitled, “What
Your Doctor May Not Tell You About Breast Cancer: How Hormone Balance
Can Help Save Your Life” .
The short of the book is that if your hormones are out of balance and
you are suffering from symptoms and conditions of advancing age, meaning
the transition into menopause
and beyond, then you should replenish your hormones back to
physiological levels with the same hormones that your body made when you
were healthy early middle age. This meant if you were to use estrogen
replacement therapy (ERT) you would replace with estradiol and/or
estriol, not a synthetic estrogen like ethinyl estradiol (synthetic
estrogen found in birth control pills) or a conjugated horse estrogen
(Premarin). And if you were taking a progestogen to help balance the
estrogen and protect against its proliferative effects, use bioidentical
progesterone, not a synthetic progestin like medroxyprogesterone
acetate (Provera) or other synthetic “fake” progesterone. We already
knew from earlier studies published several years before WHI that the
synthetic progestins were increasing the incidence of breast cancer [3, Chapter 11].
As a research scientist at that time, who had spent 20+ years
researching and publishing on the role of estrogen and progestogen
binding to their receptors and regulating breast cell proliferation and
differentiation, it was clear to me from the research literature and
smaller clinical studies that the natural hormone progesterone, when
delivered topically at a physiological dose (25 mg) protects normal
breast tissue from the growth promoting actions of estrogens . In the breast cancer book 
we delved into a lot more of what the scientific literature says causes
breast cancer and what can be done to help prevent it, like avoid bad
foods and environmental chemicals, make sure you’re eating good
nutritious foods with plenty of colored vegetables, exercise in
moderation, get adequate sleep in the dark, reduce stress as much as
possible to lower cortisol-induced estrogen, and take nutritional
supplements that bolster the army of antioxidants that protect against
environmental toxins that convert good estrogens to bad ones [5,6].
And if your hormones are out of balance, based on testing their levels
in body fluids that represent the bioavailable fraction that enters
cells, use physiological amounts of bioidentical hormones to adjust them
to levels when you were younger and healthy. What has been crystal
clear is that bioidentical hormone therapy, if used correctly and in
physiological amounts, will significantly reduce risk but is no
guarantee you will never develop breast cancer.
Synthetic Progestins Raise Breast Cancer Risk
Fast forward about 20 years to present; several more recent
meta-analyses of the risk of breast cancer with FDA-approved, or
equivalent for non-US countries, estrogen and progestogen therapies,
shed some new light on risk of HRT for breast cancer. These studies (US,
British) mostly just reiterated what we already knew: that estrogen
therapy only increases breast cancer risk slightly, but significantly
when combined with synthetic progestins .
The meta-analysis of prospective studies of slightly over 100,000 women
using estrogen alone or estrogen combined with progestogens (mostly
synthetic), but also oral progesterone ,
revealed that estrogen therapy alone was only associated with a slight
increase in risk, but when combined with a synthetic progestin the risk
was approximately doubled after 5 years and doubled again at 10 years of
use. No question, synthetic progestins were bad for the breasts and
should not be used, especially by women who want to reap the many
benefits of hormone therapies their entire lives, who should avoid
synthetic progestins. Most surprising was that this study also reported
that FDA-approved oral bioidentical progesterone, combined with
estrogen, carried the same approximately 2-fold higher risk at 5-10
years, but strangely had no increased risk less or greater than that .
No data were available for topical progesterone combined with
estrogens, perhaps because very few, if any, clinical studies have been
carried out in the US or Great Britain and surrounding European
countries using natural progesterone delivered topically.
Topical versus Oral Progesterone
Oral progesterone, while it protects the
endometrial lining, may not raise progesterone to a level high enough to
counter the growth-promoting actions of estrogens in the breast tissue.
Despite research and small clinical studies showing that natural
progesterone delivered topically directly to the breasts of humans 
and primates protects against estrogen-stimulated cell proliferation of
normal mammary epithelial cells, a risk factor for breast cancer,
surprisingly no large prospective randomized clinical studies have been
carried out to investigate if topical progesterone therapy is associated
with reduced risk for developing breast cancer. The reason for this is
not based on science, but economics. Progesterone cannot be patented;
however, progesterone combined with a special delivery system can be, as
seen with several forms of FDA-approved oral progesterone (Prometrium
and Bijuva). Oral progesterone, however, while it protects the
endometrial lining, may not raise progesterone to a level high enough to
counter the growth-promoting actions of estrogens in the breast tissue .
Factors Influencing Estrogen Metabolism to Mitigate Risk
What is clear is that anything that reduces excessive estrogen
burden, be it progesterone, natural or synthetic aromatase inhibitors,
diet with more fiber and phytochemicals with colored vegetables,
exercise, stress reduction, better sleep habits, etc., translates to
lower breast cancer risk. That is what progesterone does. It lowers cell
proliferation by down-regulating estrogen receptors (ER), preventing
further estrogen-mediated stimulation of cell proliferation and
redirects differentiation through progesterone interaction with
estrogen-regulated cellular progesterone receptors (PR). Progesterone,
via its activation of 17β-hydroxysteroid dehydrogenase type 2 (see
diagram below), also increases the conversion of estradiol, a potent
estrogen with high affinity for cellular ERs, to estrone, a weak inert
Progesterone also enhances synthesis of sulfotransferase, an enzyme
that then sulfates estrone to estrone sulfate, which is unable to enter
cells and serves as a circulating estrogen precursor that must be
converted back through two enzymatic steps, sulfatase and
17β-hydroxysteroid dehydrogenase type 1, to estradiol.
Diagram depicts the
progesterone-regulated metabolism of E2 to E1 and then to E1-SO4, and
then Cyp1A1 and Cyp1B1 conversion, respectively, to 2- and 4-hydroxy
estrogens and their further oxidation to 2- and 4-quinones. For details
see reference .
Progesterone’s Effects on Estrogen-Stimulated Cell Proliferation
What is poorly understood in the scientific/clinical community is
that progesterone has dual actions in its effects on estrogen-stimulated
cell proliferation. At the lower luteal levels (about 1-10 ng/mL)
progesterone synergizes with estrogen to promote cell proliferation with
little differentiation. If insufficient progesterone is produced in the
presence of high estradiol, as often occurs at perimenopause with
compromised luteal function, proliferation may be higher than with
estradiol alone .
However, at higher luteal levels (10-30 ng/mL) progesterone counters
the growth-promoting actions of estrogen by down-regulating ER, and
through induction of cellular PR redirects the cellular machinery to
drive quiescence and differentiation, causing proliferation to come to a
halt. If inadequate progesterone is present, as often happens at the
transition to menopause (perimenopause) when the corpus luteum fails to
produce adequate progesterone but abundant estrogen (low
progesterone/estradiol ratio), then the combination of higher
physiological estrogen and lower luteal progesterone (in range, but
low-normal) will often result in persistent proliferation and the
clinical manifestation of fibrocystic and painful breasts. Excessive
proliferation in the absence of progesterone increases risk for gene
mutations that have the potential to lead to increased breast cancer
Risks Greatest During the Menopausal Transition
Retrospective clinical studies have shown that
the higher the luteal progesterone level 5 years prior to breast cancer
diagnosis, the lower the risk of developing breast cancer.
As shown in the diagram above, estrogens in excess, in the absence of
progesterone and with exposure to environmental toxins, induce the
cytochrome enzyme Cyp1B1 that converts beneficial estradiol to
potentially toxic and mutagenic 4-catechol estradiol [5,6].
During this perimenopausal transition is when the rate of increase of
breast cancer is greatest. Retrospective clinical studies have shown
that the higher the luteal progesterone level 5 years prior to breast
cancer diagnosis, the lower the risk of developing breast cancer ,
so it is important to keep progesterone balanced with estradiol,
especially during the menopause transition when estrogen metabolite
damage is most likely to occur, as shown in a recent study on estrogen
metabolite formation and breast cancer risk .
As mentioned, oral progesterone, because it is mostly degraded
(90-95%) in the GI tract and liver to metabolites with no capacity to
bind and activate PR, may not reach sustained luteal levels to counter
the growth-promoting actions of estrogens. Based on saliva, capillary
blood, and tissue levels of progesterone, only topically applied
can achieve capillary blood and tissue levels of progesterone high
enough to counter the proliferative actions of estrogens. While small
clinical studies have shown that topical progesterone used at
physiological dosing (25-50 mg) effectively reduces estrogen-induced
proliferation of the mammary epithelium in humans ,
this form of therapy has not been tested in a large scale prospective
case-control randomized study as with FDA-approved conjugated equine
estrogens in combination with synthetic progestins [1,2].
What might we learn from what we know about the dual actions of
progesterone as it relates to bioidentical estrogen and progesterone
therapies for menopausal women and their risk for breast cancer? If we
let mother nature be our guide, then we should strive to keep estrogen
within the physiological ranges seen throughout a full monthly cycle
(about 50-150 pg/mL in serum or about 2% of that seen in saliva, 1-3
pg/mL). For at least half of the month serum or capillary blood (Dried Blood Spot, DBS) progesterone should be about 10-30 ng/mL and saliva
200-600 pg/mL. This results in a progesterone/estradiol ratio of about
100-300, which is consistent with the ratio seen at the peak of the
luteal phase and shown to be protective of the breasts exposed to
estradiol . Excessive estradiol or too little progesterone will result eventually in estrogen dominance
and symptoms of estrogen excess (e.g., weight gain in the hips and
thighs, fibrocystic and painful breasts, mood swings, etc.) Those are
warning signs. High levels of 4-catechol estrogens ratchet that up to
extreme warning  as we have found that 4-catechol estrogens are much
higher in women harboring breast cancers than healthy women .
Many providers believe that topical progesterone is ineffective because it doesn’t raise serum levels. To the contrary, we  and others [4,10]
have shown that physiological dosing with topically delivered
progesterone raises the progesterone to physiological levels in tissues
of the body such as the salivary gland, and capillary beds of the finger
tips. High dose progesterone (> 50 mg), in an attempt to achieve
physiological concentrations in serum never does this, regardless of the
topical progesterone dose .
What may seem paradoxical based on serum levels is that excessive
progesterone and too little estrogen will eventually keep ER
persistently down-regulated and may precipitate symptoms of estrogen
deficiency with weight gain, vasomotor symptoms, excessive sleepiness,
etc. Keep in mind that estradiol and progesterone are produced in a
rhythmic pattern each month. Estradiol rises slowly throughout the first
half of the cycle and peaks about midway with ovulation. This
stimulates growth and proliferation of the uterus and breasts.
Progesterone will not work if there is no cellular PR, which requires
adequate ER. Excessive progesterone down-regulates ER, stopping the
In summary, maintaining estradiol levels in balance with natural
progesterone is necessary to achieve optimal clinical benefits of these
hormones. It is the opinion of this author that these goals for optimal
progesterone therapy as a breast cancer preventive can best be achieved
with topical progesterone, and not oral progesterone, or a synthetic
progestin. However, clinical studies with topical progesterone are
needed to confirm this hypothesis.
While you go through the stages of menopause, it is important to get
your hormone levels checked to ensure that you are within physiological
levels. If you are going into, in the middle of, or at the end of your
menopause journey, ZRT’s saliva and blood spot testing can give you the information necessary to get your hormones balanced and get you back to optimal health.
This article was first published in the American Academy of Anti-Aging Medicine (A4M) Winter 2019 Issue.