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Gut Health, Disease, Vit. D

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Gut Health, Disease, Vit. D

Story at-a-glance

  • A significant proportion of your immune system resides in your gastrointestinal tract. Harvard researchers have now identified the specific population of gut bacteria that modulate localized and systemic immune responses to ward off viral invaders
  • Bacteroides fragilis and other bacteria in the Bacteroides family initiate a signaling cascade that induces the release of interferon-beta, which protects against viral invasion by stimulating immune cells to attack the virus and causing virus-infected cells to self-destruct
  • Zonulin-mediated gut permeability plays a determining role in the pathogenesis of many chronic inflammatory diseases. Zonulin is produced in response to bad bacteria. It flushes the bacteria out by opening up the tight junctions
  • Aside from bacteria overgrowth, gluten is a powerful trigger of zonulin release as the zonulin pathway misinterprets gluten as a potential harmful component of a microorganism
  • Chronic inflammatory diseases associated with dysregulation of the zonulin pathway and leaky gut include autoimmune disorders, metabolic disorders, intestinal diseases, neuroinflammatory diseases and cancer of the brain and liver

More attention than ever is being put on your gut health, and understandably so, considering a significant proportion of your immune system resides in your gastrointestinal tract.1 As such, optimizing your gut microbiome is a worthwhile pursuit that will have far-reaching effects on your physical health and emotional well-being.

Mounting scientific evidence also continues to suggest a large component of nutrition centers on nourishing health-promoting bacteria in your gut (and elsewhere in and on your body). In doing so, you keep harmful microbes in check and shore up your protection against chronic disease.

Disease Begins in Your Gut

ADHD, autism, learning disabilities, obesity, diabetes2 and Parkinson’s disease are but a few of the conditions found to be influenced by your gut microbiome. One 2020 scientific review3 goes so far as to say that all inflammatory disease begins in the gut. Part of the blame is laid on excessive hygiene. In other words, we’re “too clean” for our own good.

But your diet also plays a crucial role. The paper specifically addresses the role of zonulin-mediated gut permeability in the pathogenesis of chronic inflammatory diseases (CIDs). According to the author, Dr. Alessio Fasano,4 a pediatric gastroenterologist, researcher and director of the Center for Celiac Research and Treatment:5

“Apart from genetic makeup and exposure to environmental triggers, inappropriate increase in intestinal permeability (which may be influenced by the composition of the gut microbiota), a ‘hyper-belligerent’ immune system responsible for the tolerance-immune response balance, and the composition of gut microbiome and its epigenetic influence on the host genomic expression have been identified as three additional elements in causing CIDs.

During the past decade, a growing number of publications have focused on human genetics, the gut microbiome, and proteomics, suggesting that loss of mucosal barrier function, particularly in the gastrointestinal tract, may substantially affect antigen trafficking, ultimately influencing the close bidirectional interaction between gut microbiome and our immune system.

This cross-talk is highly influential in shaping the host gut immune system function and ultimately shifting genetic predisposition to clinical outcome. This observation led to a re-visitation of the possible causes of CIDs epidemics, suggesting a key pathogenic role of gut permeability.

Pre-clinical and clinical studies have shown that the zonulin family, a group of proteins modulating gut permeability, is implicated in a variety of CIDs, including autoimmune, infective, metabolic, and tumoral diseases. These data offer novel therapeutic targets for a variety of CIDs in which the zonulin pathway is implicated in their pathogenesis.”

Bacteria, Not Genes, Rule Your Health Destiny

Fasano points out that we simply do not have enough genes to account for the myriad chronic diseases that can beset us. Genes also cannot explain the timing of disease onset. To solve these mysteries, we must look to the microbiome, he says, as “it is the interplay between us as individuals and the environment in which we live that dictates our clinical destiny.”

Aside from the microbes themselves, the condition of your intestinal mucosa also plays a significant role. “Although this enormous mucosal interface (200 m2) is not apparently visible, it plays a pivotal role through its dynamic interactions with a variety of factors coming from our surrounding environment, including microorganisms, nutrients, pollutants and other materials,” Fasano explains.

While intracellular tight junctions used to be thought of as static and impermeable, we now know this is not the case. As explained by Fasano, zonulin is a powerful modulator of intestinal permeability. However, while zonulin is a biomarker of gut permeability and plays a pathogenic role in in many chronic inflammatory diseases, not all CIDs are caused by leaky gut.

Proposed Chain of Events Leading to CID

The graphic below, included in Fasano’s review but originating from an earlier paper6 titled “Zonulin, a Regulator of Epithelial and Endothelial Barrier Functions, and Its Involvement in Chronic Inflammatory Diseases,” co-written by Fasano and Craig Sturgeon, details the “proposed chain of events leading to chronic inflammatory disease.”

loss of mucosal immune homeostasis

Under normal circumstances, a healthy homeostasis is maintained in your gut lining such that when an antigen is encountered, no excess immune reaction occurs (anergy). Under No. 2 in the graph, gut dysbiosis is setting in (i.e., an imbalance in the number and diversity of your gut microflora), causing excess production of zonulin, which in turn makes the gut lining more permeable.

According to Fasano, the two most powerful triggers of zonulin release are bacteria overgrowth and gluten. Zonulin is produced in response to bad bacteria7 — it helps flush the bacteria out by opening up the tight junctions — so bacteria overgrowth makes sense. But why does it respond to gluten?

Interestingly enough, the zonulin pathway misinterprets gluten as a potential harmful component of a microorganism. That’s why gluten triggers zonulin release. While not mentioned by Fasano, the herbicide glyphosate also triggers zonulin, and is 10 times more potent than gluten!8

The subsequent permeability allows microbiota-derived antigen and endotoxin to migrate from the lumen to the lamina propria (the connective tissue that is part of the mucous membrane lining your intestine), thereby triggering inflammation.

As the process continues to worsen (No. 3 in the graph), your adaptive immune response kicks in, triggering the production of proinflammatory cytokines, including interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). These cytokines further worsen the permeability, thus creating a vicious cycle. Eventually (No. 4), mucosal tolerance is completely broken, resulting in the onset of a chronic inflammatory disease.

Chronic Inflammatory Diseases Linked to Leaky Gut

The specific chronic inflammatory disease that ultimately emerges at the end of all this depends in part on your genetic makeup, in part on the types of exposures you’ve had, and in part on the composition of your gut microbiome. As explained by Fasano:9

“Besides genetic predisposition and exposure to environmental triggers, the pathogenesis of a variety of CIDs seems to involve mutually influenced changes in gut permeability/Ag trafficking, immune activation, and changes in composition/function of the gut microbiome.

Zonulin is a modulator of both epithelial and endothelial barrier functions … Gut dysbiosis may cause the release of zonulin leading to the passage of luminal contents across the epithelial barrier causing the release of pro-inflammatory cytokines that themselves cause increased permeability establishing a vicious loop leading to massive influx of dietary and microbial Ags triggering the activation of T cells.

Depending on the host genetic makeup, activated T cells may remain within the GI tract, causing CID of the gut … or migrate to several different organs to cause systemic CID.”

Chronic inflammatory diseases associated with dysregulation of the zonulin pathway include:

  • Autoimmune disorders such as Celiac disease, Type 1 diabetes, inflammatory bowel disease, multiple sclerosis and ankylosing spondylitis
  • Metabolic disorders such as obesity, insulin resistance, nonalcoholic fatty liver disease, gestational diabetes, hyperlipidemia and Type 2 diabetes
  • Intestinal diseases such as irritable bowel syndrome, non-celiac gluten sensitivity and environmental enteric dysfunction (a chronic disease affecting the proximal intestine)
  • Neuroinflammatory diseases such as autism spectrum disorder, schizophrenia, major depressive disorder and chronic fatigue/myalgic encephalomyelitis 
  • Brain and liver cancers

Gut Microbes Influence Genes and Can Influence Cancer Risk

While the inclusion of cancer on that list may seem odd at first glance, some researchers believe the gut microbiome may actually end up being a game-changer for cancer prevention and treatment.

Not only have gut bacteria been shown to influence gene expression,10,11 turning some genes on and others off, research12 published in 2018 found gut microbes actually control antitumor immune responses in your liver, and that antibiotics can alter the composition of immune cells in your liver, triggering tumor growth.

Harvard Medical School researchers have identified the specific population of gut microbes that modulates both localized and systemic immune response to ward off viral invaders.

Certain gut bacteria also promote inflammation, which is an underlying factor in virtually all cancers, whereas other bacteria quell it.13 The presence of certain gut bacteria has even been shown to boost the patient’s response to anticancer drugs.14

One way in which gut bacteria improve the effectiveness of cancer treatment is by activating your immune system and allowing it to function more efficiently. Researchers have actually found that when these specific microbes are absent, certain anticancer drugs may not work at all.

Gut Bacteria Are Part of Your Antiviral Defense

Gut bacteria are also involved in your antiviral defense, recent research15 shows. As reported by Harvard Medical School November 18, 2020:16

“For the first time, Harvard Medical School researchers have … identified the specific population of gut microbes that modulates both localized and systemic immune response to ward off viral invaders. The work … pinpoints a group of gut microbes, and a specific species within it, that causes immune cells to release virus-repelling chemicals known as type 1 interferons.

The researchers further identified the precise molecule — shared by many gut bacteria within that group — that unlocks the immune-protective cascade. That molecule, the researchers noted, is not difficult to isolate and could become the basis for drugs that boost antiviral immunity in humans.”

While the findings still need to be replicated and confirmed, they point to the possibility that you might be able to enhance your antiviral immunity by reseeding your gut with Bacteroides fragilis and other bacteria in the Bacteroides family.17

These bacteria initiate a signaling cascade that induces the release of interferon-beta that protect against viral invasion by stimulating immune cells to attack the virus and causing virus-infected cells to self-destruct.

“Specifically, … a molecule that resides on the bacterium’s surface triggers the release of interferon-beta by activating the so-called TLR4-TRIF signaling pathway,” Harvard explains.18 “This bacterial molecule stimulates an immune-signaling pathway initiated by one of the nine toll-like receptors (TLR) that are part of the innate immune system.”

The Role of Vitamin D

Recent research also highlights the role of vitamin D in gut health and systemic autoimmunity. The review article, published January 21, 2020, in Frontiers in Immunology, notes:19

“Autoimmune diseases tend to share a predisposition for vitamin D deficiency, which alters the microbiome and integrity of the gut epithelial barrier.

In this review, we summarize the influence of intestinal bacteria on the immune system, explore the microbial patterns that have emerged from studies on autoimmune diseases, and discuss how vitamin D deficiency may contribute to autoimmunity via its effects on the intestinal barrier function, microbiome composition, and/or direct effects on immune responses.”

As noted in this review, vitamin D has several direct and indirect regulatory effects on your immune system, including promoting regulatory T cells (Tregs), inhibiting differentiation of Th1 and Th17 cells, impairing development and function of B cells, reducing monocyte activation and stimulating antimicrobial peptides from immune cells.

That said, the relationship between vitamin D and autoimmunity is complicated. Aside from immunosuppression, vitamin D also appears to improve autoimmune disorders by the way it affects your microbiota composition and gut barrier.

The review cites research showing that your vitamin D status alters the composition of your gut microbiome. Generally speaking, vitamin D deficiency tends to increase Bacteriodetes and Proteobacteria while higher vitamin D intake tends to increase prevalence of Prevotella and reduce certain types of Proteobacteria and Firmicutes.

While research is still slim when it comes to vitamin D’s impact on gut bacteria, especially in patients with autoimmune disease, vitamin D deficiency and autoimmune diseases are known comorbidities and vitamin D supplementation is often recommended for these patients.

Vitamin D Required for Tight Junction Maintenance

Better known is how vitamin D supports intestinal and immune cell defenses in the gut. In fact, vitamin D is one of the crucial components required for maintaining tight junctions. As explained in this review:20

“The intestinal epithelium is in constant interaction with the external environment. Adequate barrier integrity and antimicrobial function at epithelial surfaces are critical in maintaining homeostasis and preventing invasion or overcolonization of particular microbial species.

A healthy intestinal epithelium and intact mucus layer are critical to protect against invasion by pathogenic organisms, and vitamin D helps to maintain this barrier function … Multiple studies found that vitamin D3/VDR signaling modulates tight junction protein quantity and distribution …

As a ‘leaky’ protein that allows movement of ions into the intestinal lumen, claudin-2 expression in the setting of functional vitamin D deficiency may contribute to colitis pathology …

Vitamin D upregulates antimicrobial peptide mRNA and protein expression including cathelicidin, defensins, and lysozyme … Antimicrobial peptides, primarily secreted by Paneth cells in the gut, are important mediators of microbiome composition … Defensins are secreted by epithelial cells, Paneth cells, and immune cells, and are important components of the innate immune response in the gut.”

How Vitamin D May Contribute to Autoimmune Disease

According to the authors, vitamin D deficiency may contribute to autoimmune disease by affecting the microbiome and the immune system in the following manner:

  1. Vitamin D deficiency or supplementation changes the microbiome, and manipulation of bacterial abundance or composition impacts disease manifestation.
  2. Lack of vitamin D signaling due to dietary deficiency can impair physical and functional barrier integrity of the gut, thereby allowing bacterial interactions to either stimulate or inhibit immune responses.
  3. Your innate immunologic defenses may be compromised if you are deficient in vitamin D.
vitamin D deficiency may contribute to autoimmune disease

How to Optimize Your Gut Microbiome

All of this information should really drive home the point that optimizing your gut flora and vitamin D level is of crucial importance for good health. By reseeding your gut with beneficial bacteria, you can keep pathogenic microbes and fungi in check and prevent them from taking over, and optimizing your vitamin D will help avoid leaky gut.

Regularly eating traditionally fermented and cultured foods is the easiest, most effective and least expensive way to make a significant impact on your gut microbiome. Healthy choices include lassi (an Indian yogurt drink), cultured grass fed organic milk products such as kefir and yogurt, natto (fermented soy) and fermented vegetables of all kinds.

Although I’m not a major proponent of taking many supplements (as I believe the majority of your nutrients need to come from food), probiotics are an exception if you don’t eat fermented foods on a regular basis. Spore-based probiotics, or sporebiotics, can be particularly helpful when you’re taking antibiotics. They’re also an excellent complement to regular probiotics.

Sporebiotics, which consist of the cell wall of bacillus spores, will help boost your immune tolerance, and because they do not contain any live bacillus strains, only its spores — the protective shell around the DNA and the working mechanism of that DNA — they are unaffected by antibiotics.

Antibiotics, as you may know, indiscriminately kill your gut bacteria, both good and bad. This is why secondary infections and lowered immune function are common side effects of taking antibiotics. Chronic low-dose exposure to antibiotics through your food also takes a toll on your gut microbiome, which can result in chronic ill health and increased risk of drug resistance. Last but not least, you also need to avoid things that disrupt or kill your microbiome, and this includes:

  • Antibiotics, unless absolutely necessary
  • Conventionally-raised meats and other animal products, as these animals are routinely fed low-dose antibiotics, plus genetically engineered and/or glyphosate-treated grains
  • Processed foods (as the excessive sugars feed pathogenic bacteria)
  • Chlorinated and/or fluoridated water
  • Antibacterial soap and products containing triclosan

5-HTP

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Synthesized from the amino acid tryptophan, 5-hydroxytryptophan (5-HTP) is the rate-limiting precursor to serotonin and melatonin, our relaxation hormones that are important for proper sleep. 5-HTP supplementation has been shown to be useful in enhancing serotonin levels in humans, which is why it is most known for its role in helping with depression.

5-HTP has shown promise with sleep disorders and insomnia, especially increasing rapid eye movement (REM) sleep, thus improving slow wave sleep (SWS). In fact, some studies have also shown promise with improvement of childhood sleep terrors. Much of this makes sense, given 5-HTP’s involvement in the synthesis of melatonin, known to be one of the regulatory hormones involved in the sleep-wake cycle. Serotonin (5-HT), too, has been known for its powerful sedative effects, especially after ingesting the tryptophan in a huge Thanksgiving turkey meal (although this is most likely in large part due to overeating). According to an animal study, “The similarity of the effects of 5-HTP and tryptophan suggests that they both act as serotonin precursors.”

5-HTP is not found directly in foods, but made from individual amino acids. In order to be effective, 5-HTP must cross the intestinal lining and enter the bloodstream. In a healthy gut environment, absorption occurs easily. 5-HTP readily crosses the blood-brain-barrier, moving into targeted tissues where it is then converted into the active neurotransmitter, serotonin. Studies have found that, when taken with vitamin B6, 5-HTP facilitates the manufacture of serotonin, which increases melatonin production.

Fibromyalgia, insomnia and sleep terrors are the most common conditions studied in regards to 5-HTP supplementation and sleep. During a 90-day open trial, nearly 50 percent of the patients affected by fibromyalgia patients experienced significant improvement in quality of sleep, fatigue, anxiety and pain when taking 5-HTP. Other conditions in which fatigue is a primary concern may also benefit from a similar treatment.

Insomnia in children is quickly becoming a troubling issue, affecting nearly 20 to 30 percent of young children, and leaving a plethora of trailing health and behavioral consequences. Many young children with insomnia continue to have sleep issues later in life. Lack of adequate sleep in children is often linked to physical and learning disabilities, difficult temperaments, autism, epilepsy, and attention problems, among other things. Night terrors are a common cause for sleep issues in children between the ages of 3 to 12 years. These are episodes that usually cause screaming, but can also cause sudden awakening with persistent fear, sweating, confusion and increased heart rate. In one study, children with night terrors were given 5-HTP and compared to a similar group of children who were not given 5-HTP. The results of this study indicated 83.9 percent of the children treated with 5-HTP were episode-free after six months, thus showing a hopeful solution to this particular cause of sleep insufficiency in children. Another small case study tested the effect of 5-HTP on sleep in two children with schizophrenia. After treatment with 5-HTP, increased REM and sleep improvement was noted.

In consideration of the high impact sleep deprivation has on quality of life, behavior, mood and health, it is important that practitioners deal with foundational sleep issues when considering all health complications. 5-HTP provides a good starting place for addressing sleep issues in both children and adults and has a history of safe usage. Being a derivative of serotonin, not only will 5-HTP improve sleep quality, but it will also indirectly influence mood and behavior in a positive direction. This offers a lot of hope to patients and practitioners since mood and emotions impact the healing process and the perception of wellness. Many health conditions are rooted in sleep deprivation and 5-HTP offers a safe, easy starting point for health and wellness.

NOTE#! : In my practice I often recommend a 1mg Melatonin sub-lingual tablet (Source Naturals) not at bedtime but depending on the patient, 1-4 hours prior to bedtime but never at bedtime itself.  So if you go to bed at 10, I have them take the 1 mg Melatonin at 7, 8 & 9

I additionally recommend a 50mg 5-HTP to be taken 3 hours prior to bedtime

NOTE #2: Remember the reason why people can go to sleep initially, wake up and then cannot go back to sleep is because their blood sugar is plummeting during the night. As a result we are awoken from a sound sleep which immediately increase the Cortisol levels which in turn stabilize the blood sugar.  The down side to this is that if Cortisol increases Melatonin decreases and you cannot fall back to sleep 1,2,3.

NOTE #3: You are not awakening to pee, you are awakening because of blood sugar.  By the end of 2015 or early 2016, Alzheimers will officially be referred to as Type 3 Diabetes

NOTE #4: Another new phenomenon is children who have insomnia and whose parents are either giving them pharmaceutical medications for sleep or melatonin–both of which are abhorrently disgraceful

Tags: Sleep, melatonin, depression

Measles Documented Amongst the ‘Fully Immunized’

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Measles outbreak documented among the ‘fully immunized’

There was more to the recent measles outbreak than meets the eye.  For starters many years ago in my era and before, if one kid on the block got the measles, every parent took their kids to the “measles house” so their kids would also get them.  It did not seem that many kids died

Recently on HBO’s Vice a story was done on curing cancer using viruses; and the Measles Virus amongst others, was one that was showcased.  There has always been a school of thought about viruses targeting specific cancer cells and not healthy cells. It may not be the final answer but it is certainly unbelievably interesting especially because it is cancer that is up for a possible cure!

Another factor to consider is what is known in medicine as “Viral or Bacterial Drift Mutation”. This is the intuitive phenomenon of a virus or bacteria mutating into something totally different than it originally was in order to protect itself.  This is why the flu vaccine fails along with other vaccinations such as Pertussis and MMR. 68% of those contracting Pertussis in Southern California a year or so ago were vaccinated !

All I am saying is do not let fear which is synonymous with the devil take control of your mind when it comes to Measles or any other vaccination issue.  Study, study, study and come up with your decisions based on truth and not fear.

The latest Disneyland measles outbreak proves that people can go off the rails when their sacred cows are threatened. Corporate toadies from the media went ballistic over a few children, some vaccinated, who allegedly contracted measles at Disneyland because not everyone chooses to vaccinate. One hate-spewing report from a major news outlet actually insisted that parents who oppose vaccinations should be put in jail. However, rational segments of society will recall that many earlier measles outbreaks occurred among fully vaccinated groups of people, laying waste to the official myth that vaccines provide protection against disease.

In 1987, for example, a study published in the New England Journal of Medicine (NEJM) documented a measles outbreak that occurred in Corpus Christi, Texas, in the spring of 1985. Fourteen adolescent-age students, all of whom had been vaccinated for measles, contracted the disease despite having been injected with the MMR vaccine. Researchers noted that more than 99 percent of students at the school — basically all of them — had also been vaccinated, with more than 95 percent of them showing detectable antibodies to measles.

This highly revealing study completely contradicts the official narrative being propagated today that unvaccinated individuals are responsible for disease outbreaks like the one that reportedly began at Disneyland. None of the students in Texas who contracted the measles in 1985 were unvaccinated, and virtually none of their peers were unvaccinated. Consequently, so-called “herd immunity,” which would have been activated based on what health authorities claim as indisputable immunological fact, was also shown to be an unsubstantiated myth, further vindicating the unvaccinated as a possible cause of this particular outbreak. There’s no other valid explanation for why a fully vaccinated group of children, who were surrounded by an almost fully vaccinated group of peers, contracted a disease for which they should have been immune, according to the official story. And there’s no blaming the one or two students who weren’t vaccinated for this outbreak because:

1) not a single unvaccinated student contracted the measles; and
2) herd immunity would have been activated regardless, supposedly protecting everyone.

CDC data published after 1985 reveals exceptional failure of MMR vaccine

Additionally, those who were vaccinated should have been protected by the vaccine either way — that is, if vaccines really work as claimed. They obviously don’t, which is further evidenced by data later published by the U.S. Centers for Disease Control and Prevention (CDC) in its Morbidity and Mortality Weekly Report (MMWR).

In a 1988 issue of the report, the CDC published data on measles which documented 3,655 cases of measles in 1987, the previous year. Guess how many of these cases were in vaccinated individuals? 1,903, or roughly 52 percent — more than half! So much for the effectiveness of that MMR vaccine that health authorities want you and your family to rush out and get immediately.

MMR is the same vaccine that was exposed by the CDC whistle-blower as causing autism, particularly in young African American boys. And because MMR contains attenuated (weakened) live measles virus, it can also shed from vaccinated individuals to others, which may have been behind past measles outbreaks.

There are number of possible factors here that the media is ignoring in its vicious witch hunt to demonize all those “anti-vaxxers” out there who have legitimate concerns about the safety and effectiveness of this controversial vaccine. But don’t let them bully you — it is ultimately your decision to decide what’s best for your children, even if it means foregoing what the establishment claims is the solution.

For more information:

http://www.cdc.gov

http://www.ncbi.nlm.nih.gov

http://www.naturalnews.com

Fluorides Shocking Facts

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Fluoride’s Shocking Facts

All European countries (other than Ireland) wisely banned fluoride from their drinking water decades ago.  Recent data shows that 72.4% of the US population is relegated to consume this poison from faucets and showerheads.  Ireland’s mandatory fluoride law exposes the dangers of this toxic agent—the citizens of this small nation endure one of the highest levels of neurological disease in the world.

Fluoride is a poison, affecting almost every organ in the body. It is as poisonous as arsenic and more poisonous than lead.  Historically, the Roman Empire’s demise was precipitated from lead poisoning via water. In spite of this, worldwide chemical lobbyist and their array of   ill-informed dentists propagate the use of this vile killer.

Empirical research from top universities has revealed:

  • Fluoride alters immune response by inhibiting antibody formation
  • Cancer is one disorder that is linked to fluoride consumption as is reported by the environmental protection agency (EPA)
  • Fluoride disrupts the synthesis of collagen and leads to the breakdown of collagen in bone, tendon, muscle, skin, cartilage, lungs, kidney, trachea and arteries
  • Fluoride promotes bone fractures
  • Fluoride plays a role in sleep disorders by accumulating  in the pineal gland and reducing melatonin (melatonin is necessary for sound sleep)
  • Fluoride encourages learning disabilities
  • Fluoride leads to dementia and other nerve degeneration disorders
  • Fluoride induces thyroid and glandular disease
  • Infertility is directly related to fluoride
  • Birth defects are accelerated by fluoride due to the alteration of brain function and hormones in the fetus
  • Fluoride promotes premature aging and decrease fertility
  • Animal kidneys fail at a much higher level when consuming tainted water
  • Environmental degeneration of our soil is one of fluoride’s top legacies

Prozac/Paxil Facts—Fluoride is the key ingredient in many psychotropic drugs! Prozac is 94.8% FLUORIDE!

Charts of Sodium Fluoride Content in our Food

Let’s speed up the fluoride detox

  1. Iodine supplementation has been clinically demonstrated to increase the urine excretion of sodium fluoride from the body, by changing it to the calcium fluoride form. During this process calcium is robbed from the body, another reason for taking effective calcium and magnesium supplements. Lecithin is recommended as an adjunct to using iodine for excreting fluoride.
  2. Vitamin C

There are many good organizations working to abolish fluoride’s destructive history. One example is the Fluoride Action Network.  Use any search engine (Google) in your part of the world to learn more

Additional Informational Links:   

Detox Tips – Long Term n Easy

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Acetyl-Glutathione & Intracellular Detoxification

By Jack Tips (Ph.D, CCN)

Clinical nutritionists have long recognized the premier importance and vast significance of the molecule, glutathione (GSH), in human health.  It is the body’s most important antioxidant/detoxifier, and protects the cells from free radical damage incurred during mitochondrial production of adenosine triphosphate (ATP) energy. Other cellular free radical protectors are the enzymes catalase and super-oxide dismustase. Simply put, if glutathione levels drop, the body is prone to cancer, wasting disease, autism, hepatitis, cataracts, Alzheimer’s, Parkinson’s COPD, asthma, schizophrenia, bipolar and aging—just to cite a few conditions bearing numerous medical references

Raising glutathione levels in the cells has been a challenge.  Glutathione can be put into a supplement, but it’s difficult to get it through the intestines into the bloodstream.  Once in the bloodstream, it’s difficult to get supplemental GSH into the cells as degradation occurs in the bloodstream.  Studies showed taking supplemental GSH does not raise blood levels.  Thus oral supplements were deemed  to assist in the gastrointestinal tract; perhaps some help in the blood, but not enter the cells where it’s needed.  Intravenous GSH administration became the most effective way to push GSH into the cells.

Recently, a new form of GSH became available—one that demonstrates it can be absorbed through the G.I. tract and survive degradation in the bloodstream, cross cell membranes and thus favorably impact the cells, as well as help prevent cancer.  It is acetyl-glutathione featured in Systemic Formulas’ GCEL.

S-Acetyl Glutathione is an alternative frm of the reduced GSH. Several studies have shown that this precursor of GSH is well absorbed and more stable throughout the digestive tract than the reduced       L-glutathione and has a positive effect on many oxidative stress bio-markers.  S-Acetyl  Glutathione enters the cell directly and once inside the cell it is converted to GSH by the cytoplasmic thioesterases that remove the acetyl group thus rapidly raising Intracellular GSH levels.

Because of GSH ability to promote detoxification from within the cells, its supplementation can flood the detox pathways and cause large amounts to enter the small intestines via gall bladder excretion via the bile.  To prevent resorption from the intestines, practitioners utilize BIND (Toxin Elimination), a superactived charcoal, to absorb and bind toxins so they cannot be resorbed.  Together GCEL and BIND assist the body in “removing the cause” of inflammation, hormone resistance, cell membrane damage, and errant cell metabolic processes.

NOTE: In clinical practice, detoxification proponents often employ the 60 Day Systemic Detoxification Program to help the body clear out the interfering toxin backlog, improve liver function, open detoxification pathways, and impact cellular metabolism with protective antioxidants.  Then boosting GSH to drive the detoxification effort into the cellular processes offers the body an amazing opportunity to rejuvenate its cellular functions from which a more optimal health can be restored.  Systemic’s Intracellular Detoxification program provides state of the art true cellular detoxification support that serves the brain, cells, and innate healing processes.