Biofilms & Silver

Here is another piece on Biofilms.  In this piece, Silver is mentioned as one of the most effective ways to prevent drug resistance due to biofilms as most of my patients know, I have used and recommended MSP Mild Silver Protein for decades.  This is not Colloidal, it is silver protein.  500 ppm (parts per million) makes it very accessible to penetrate cell membranes.  You will also read about Japanese Knotweed which I also use in Resveratrol. No better Resveratrol than that which originates from Knotweed.

Biofilms and Resistance

When deliberating the causes of drug resistance, the finger could be pointed at numerous roots: indiscriminate overuse of antibiotics, modern food animal production, or the global presence of antibiotic residues in the environment. In some cases such as B. burdorferi, the causative agent of Lyme disease, the bacteria eludes treatments by assuming various forms and habitations. However, one previously unknown root that is now coming to full light is microbial biofilms. Biofilms are an adhesive matrix of polysaccharides, protein and DNA, self-produced by a colony of microbes, as a type of insulation against both foreign and native defenses. The biofilm is extraordinarily resistant to antimicrobial agents and phagocytosis. It provides a safe haven for gene transfer, microbial replication, efficient metabolism and the persistence of chronic infection. The presence of biofilms is now being recognized as the causative agent for drug resistance in many chronic infections. The application of biofilm-destroying agents is becoming essential if practitioners intend to fully eliminate certain resistant infections.Silver is a highly effective, ancient antimicrobial never known to provoke resistance nor toxicity. However, modern technology has moved away from the use of traditional silver ions (including colloidal silver) to the more potent silver nanoparticles, which have the ability to fight biofilms in addition to silver’s numerous antimicrobial properties. Silver nanoparticles are extraordinarily small (1 to 100nm), allowing full penetration of microbial cell walls and interaction at the genetic level. One study employed the use of 100μM of silver nanoparticles on P. aeruginosa and S. epidermidis and found a 95 to 98 percent decrease in biofilm production, after only 2 hours of treatment. When applied to other drug-resistant microbes, including MRSA, silver nanoparticles inhibited biofilm production with the same efficacy. Silver nanoparticles are multifaceted antimicrobial agents whose depth of action exceeds others in its class, while promising no resistance.

Proteolytic enzymes offer another method for destroying biofilms. Proteolytic enzymes act as fibrolytic agents and functionally dissolve the fibrous matrix of biofilms. This allows traditional antimicrobial agents access to the microbes within. Therefore, proteolytic enzymes are used synergistically with antimicrobial agents and enhance their effect. Two common proteolytic enzymes are nattokinase and serrapeptase. Nattokinase disassembles amyloid-like fibers of the biofilm matrix. The specific actions of serrapeptase are not so clear, but its effectiveness in dissolving biofilms is quite clear. In one study, serrapeptidase was able to eradicate more biofilm-forming S. epidermidis, due to its action against the biofilm, compared to antibiotic therapy alone. Proteolytic enzymes such as nattokinase and serrapeptase are ideal choices for pairing with antibiotics and/or antimicrobials to ensure biofilms are destroyed and treatment is effective.

Many plant extracts have shown anti-biofilm activity. Japanese knotweed (Polygonum cuspidatum) is one extract well regarded for its anti-biofilm activity and employed in the management of oral biofilms and those produced by B. burdorferi, leading to chronic Lyme disease. The management of acne vulgaris is becoming increasingly complex since long-term tetracycline use has fostered biofilm formation and antibiotic resistant P. acnes. However, Japanese knotweed was shown to inhibit P. acnes biofilm production by 99.2 percent, improving treatment outcome significantly. Japanese knotweed owes its powerful anti-biofilm actions to its rich supply of resveratrol, a compound often associated with red wine, but abundant in many plant extracts. Resveratrol, from red wine, was also found to significantly inhibit the biofilm of Staphylococcus aureus, strengthening the argument for its use in the management of common antibiotic resistant infections.

Metal nanoparticles, enzyme therapy and botanicals represent the diversity that exists among agents that fight biofilms. As the need for these agents grows, this diversity may prove to be a true lifesaver as the threat of drug resistance and chronic infection looms over the horizon and warns of its potential consequences.

For additional information or to place an order for Mild Silver Protein or the Japanese Knotweed, call me at 619-231-1778 or e-mail [email protected]

Grapefruit Seed Sinus +++

Add 4 drops of Grapefruit Seed Extract and 1/4 teaspoon of sea salt to 8 ounces of warm water. Allow the salt to dissolve in the water. Use the solution to irrigate the nasal cavities using a Neti pot or nasal spray bottle.

I use pharmaceutical grade–but the  product  in the picture will work just fine and is available at all stores such as Sprouts, Whole Foods, etc.

Here are some other uses for GSE.  I have used it since I began practice, let it go and now after studying with the French who use GSE extensively, I am bringing it back.


Note: Never use the Grapefruit Seed Extract Concentrate at full strength, as it may cause irritation

Orally – Suggested Use: Use the GSE Mouthwash or 5 to 15 drops of concentrate mixed in 5 ounces of water or juice, 2 to 5 times daily, with or without meals. (Or, take one-two NutriBiotic Capsules Plus® or one-two NutriBiotic® tablets 1 to 5 times daily). Children(under 10 years): 1 to 6 drops mixed in 5 ounces juice, 2 to 3 times daily. Do not use full strength in mouth.

Dental Rinse For Healthy Gums and Fresh Breath: Use the GSE Mouthwash or stir 3 drops of NutriBiotic into 2 oz. or more of water. Vigorously swish a small amount of the water for 10 seconds or more, 1 to 2 times daily. Also works as an additive for Waterpik® type units. Add 3 to 4 drops to the water reservoir. Always dilute.

Throat Gargle: Use the GSE Mouthwash or stir 3 drops of NutriBiotic into a small(3 ounces or so) glass of water. Gargle several times. Use as often as needed. Always dilute.

Ear Rinse: Use the GSE Ear Drops or thoroughly mix 4 to 10 drops of NutriBiotic into one ounce of glycerin or alcohol. Apply 1 to 2 drops of this solution in affected ear 1 to 2 times daily. Use as often as needed. Do not use full strength in ears.

Nasal rinse: Use the GSE Nasal Spray or Mix 1 drop NutriBiotic with 2 ounces of water. With your head tilted back, fill each nostril with a full eye-dropper of the mixed solution. Swing head forward and down(head is now upside down) to force the solution up into nasal passages. Return head to the normal upright position and allow nasal passages to drain. Do not inhale through the nose during this process. Always dilute.

Vaginal Rinse: – Mix 5 to 10 drops of NutriBiotic in 6 to 8 ounces of water. Douche once daily for one week. Douche more often if desired. Always dilute


Facial Cleanser: Thoroughly moisten(splash) face with warm or cool water. With hands still wet, apply 2 to 3 drops of NutriBiotic to fingertips and gently massage facial area with circular motions. Rinse thoroughly with cool water and pat dry. A tingling sensation may follow. This is an indication of the deep cleansing properties of NutriBiotic. Always dilute.

Skin Rinse: (For minor skin irritations) Dilute NutriBiotic with water(5 to 10 drops/ tablespoon). Apply this solution directly to affected area twice daily. Do not use full strength on skin.

Finger/Toe Nail Treatment: Dilute NutriBiotic with water or alcohol(5 to 10 drops/tablespoon). Apply this solution directly on surface of nail along the cuticle and underneath the front of nail, or soak nails, twice daily, for as long as desired. Do not use full strength on nails.

Scalp treatment: Add 5 to 10 drops of NutriBiotic to each shampooing(mix in hand or on head with shampoo). Massage into scalp and leave on for at least two minutes. Rinse off thoroughly with water. May also be used without shampoo