Endometriosis Estrogen Dominant Disease

Endometriosis: A Disorder of Estrogen Dominance

This post is a Segway to the original Endometriosis post from the Guardian. Please read both!

Estrogen is the hormone that makes women “women,” in its support of the female organs that support human life. It initiates the development of sex characteristics at puberty by stimulating the growth of endometrial and breast tissue. Every month it stimulates the growth of the follicle which releases the egg. It supports vaginal tissues and stores fat to support a woman who might become pregnant or nursing. Other growth-related processes attributed to estrogen are preventing bone loss and maintaining collagen in the skin and connective tissues. Estrogen also aids in the synthesis of neurotransmitters, especially serotonin and dopamine, and supports the transportation of glucose across the blood brain barrier.

While estrogen contributes to fertility and a woman’s monthly cycle, it can run amok when it goes unchecked by enough progesterone, the hormone that promotes differentiation. A common presentation of unbalanced estrogen is endometriosis. Endometriosis is the presence of endometrial-like tissue outside of the uterus, primarily located on the pelvic peritoneum, ovaries and recto vaginal septum. Endometriosis has a high association with adenoymyosis, endometrial tissues growing outside of the uterine wall; and fibroids, a benign tumor of muscular tissue in the wall of the uterus.

Endometriosis and its cousins adenomyosis and uterine fibroids, often difficult to tell apart, are the reasons that many women experience pelvic pain and bleeding, and make visits to their gynecologists. While only 6-10% of women of reproductive age experience endometriosis, 50-60% of the pelvic pain experienced by teenage girls is caused by endometriosis, and endometriosis is present in 50% of women with infertility.

Endometriosis is also associated with inflammation, in the form of elevated cytokines and homocysteine. These cytokine elevations put a woman at higher risk for autoimmune diseases such as Crohn’s and Ulcerative Colitis, Grave’s, Hashimoto’s, and Celiac disease. Amazingly, endometriosis lesions express aromatase and synthesize their own estradiol from testosterone, creating more estrogen and inflammation, and contributing to estrogen dominance! Endometriosis is also associated with an increased risk of ovarian endometrioid and clear-cell cancers, as well as other cancers such as non-Hodgkins lymphoma and melanoma.

In short, the estrogen dominance that leads to endometriosis breeds growth in the form of more endometriosis, more estrogen production and more inflammation, and may even contribute to the growth of cancer. The conventional treatment for endometriosis includes NSAIDS, GnRH agonists (Lupron), oral contraceptives, and surgery. Because progesterone tends to be decreased in women with endometriosis, progesterone supplementation can be a more natural alternative to pharmaceuticals. Progesterone can serve as an important component in breaking the cycle of estrogen dominance as it stabilizes and slows the cell growth associated with estrogen. Many women are desperate for a solution to their pain and will gladly start with a trial of progesterone.

Consider salivary hormone testing in your patients, as the Pg/E2 ratio can play an important role in determining a progesterone-based treatment plan for women with endometriosis at any age.

Check out Dr.Jocker’s Natural Solutions to Estrogen Dominance . I am especially interested in you looking at Xenoestrogenic chemicals / foods and ways to avoid them

References
1.Lotto V, Choi SW, Friso S. Vitamin B6: a challenging link between nutrition and inflammation in CVD. Br J Nutr. 2011;106(2):183-95.

Zhang D, Wen X, Wu W, Guo Y, Cui W. Elevated homocysteine level and folate deficiency associated with increased overall risk of carcinogenesis: meta-analysis of 83 case-control studies involving 35,758 individuals. PLoS ONE. 2015;10(5):e0123423.

Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389-98.

Zheleva-Dimitrova, D. Obreshkova, D. & Nedialkov, P. Antioxidant Activity of Tribulus Terrestris – A Natural Product of Infertility Therapy

Kadam PD, Chuan HH. Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament. Int Urogynecol J. 2016;27(3):505.

Sir T. [Do androgens modulate luteinizing hormone secretion in women?]. Rev Med Chil. 1997;125(6):710-8.

Endometriosis

Endometriosis: the hidden suffering of millions of women revealed

I picked up this article from the Guardian and posted it on both Facebook & Twitter. Aside from the fact it is so well written with excellent additional links, I realized many folks “out there” do not have a clear understanding of endometriosis because their doctors do not and therefore cannot explain it properly

Often dismissed as ‘women’s troubles’, endometriosis affects one woman in 10 of reproductive age, yet a lack of research and funding means sufferers can live in severe pain, unable to work or socialize
Primary care doctors often do not know what endometriosis is and large numbers of women are under-treated or badly treated for the disease.

The hidden toll and extraordinary neglect of a disease that affects an estimated 176 million women around the globe, causing many to suffer a life of pain and debilitation and sometimes infertility, is revealed by the Guardian.

One woman in 10 of reproductive age has endometriosis, it is estimated, and yet often their primary care doctors do not know what it is and the specialists to whom they are sent are ill-informed.

Endometriosis often ignored as millions of American women suffer

Vast numbers of women are under-treated or badly treated. It can take years to get a diagnosis and during that time women may suffer severe pain and are unable to work, socialize or maintain a sexual relationship.

What is endometriosis? A guide

The disease does not always have symptoms and may be the cause of half of all unexplained infertility.

Endometriosis has existed in the twilight for centuries because of society’s reluctance to discuss what was euphemistically known for so long as “women’s troubles”.

It occurs when tissue similar to the lining of the womb is found elsewhere – most commonly in the abdomen, ovaries, in the recto-vaginal septum, bladder and bowel. That tissue behaves like the lining of the womb, bleeding every month, and can cause cause severe and chronic pain . Women tell of such acute pain that they pass out.

The lack of research and funding for a disease that affects so many women is “a major scandal”, said Lone Hummelshoj, who heads the World Endometriosis Research Foundation and the World Endometriosis Society.

“Endometriosis affects women in the prime of their life. It is not a lifestyle disease. It is not a disease you get later in life. It attacks teens, young women when they should be out being active, working, having children, having sex – 50% of them are struggling with sex because it is too painful,” she said.

Endometriosis: 20 things every woman (and every doctor) should know

It has exacted a massive social cost in broken marriages and depression as well as being a huge economic burden, partly because of the large number of women who have to drop out of the workforce.

In the US, with 7.6 million women affected, the estimate was €70.9bn (£52.1bn, $80.4bn) a year; in the UK, which has 1.6 million sufferers, the cost was estimated in 2012 at €14.4bn (£10.6bn). In Australia, there may be 550,000 women affected, costing the economy A$6bn (£2.75bn).

The numbers are comparable to diabetes – and yet there is only a fraction of the awareness of the condition and help for those afflicted.

Far too many women are turned away by their doctors and told they must put up with the pain or even that they are imagining it. A Guardian online call-out to women for their stories got 600 responses in one day. A recurring theme was: “The doctors thought it was all in my head”.

Niki Dally, 33, in Wales, UK, has been suffering from endometriosis from the age of 11. She said even her mother thought she was making it up. “My mother thought I was a hypochondriac,” she said.‘I’m not a hypochondriac. I have a disease. All these things that are wrong with me are real, they are endometriosis’

“One doctor said ‘it’s in your head, girl. You have got to deal with it.’” She was prescribed medication for her nausea and vomiting and told it was irritable bowel syndrome, cysts, a UTI, eating disorders and depression.

“Aged 14, the doctors thought it might be appendicitis and admitted her to hospital. It took 10 years to get the right diagnosis, but she now lives on a cocktail of strong painkillers and is still struggling to get the right treatment”.

In the US, Heather C Guidone who works at the Center for Endometriosis Care, Atlanta, Georgia, and has herself been through 22 operations for severe endometriosis, said women are still told periods are supposed to hurt and that it’s a woman’s lot in life to suffer. “All of those cliches that have surrounded menstruation since the dawn of time. [A woman tells the doctor] ‘I have this horrible life-altering pain, and these symptoms’, then the doctor will kind of pat her on the head and say take this pill. Then you’ve got this vicious cycle, and ultimately she stops telling people.”

“Every, every possible misdiagnosis is brought on some of these women before the correct diagnosis is made. And the traumatic assertions that you’re having pelvic pain because you have an STD – the whole thing is bizarre.

Endometriosis can be mild or so severe that it takes over a woman’s life. Former Spice Girl Emma Bunton, Dolly Parton and Anna Friel all have endometriosis. So does Booker Prize-winning author Hilary Mantel and actors Susan Sarandon and Whoopi Goldberg. Marilyn Monroe is thought to have become addicted to the painkillers she took for endometriosis, which resulted in her death.

Experts say the disease is little known. “The people we have polled have never heard of it,” said Jane Hudson Jones, chief executive of the charity Endometriosis UK. “I have never come across anybody in the general public who knows about it. Yet it can be absolutely devastating.” Surveys of their own membership showed that 25% had felt suicidal because of it. “It can affect pretty much every area of your life – your work, career, income, relationships and fertility. And many are constantly in pain.”

Carol Pearson, 43, had to give up the successful career she loved because she was too ill too often. “I hated losing my career,” she said. “I worked my socks off to get to university and become a chartered accountant. I was in a management position for many years and paying taxes. I worked for my company for 13 years and they did everything they could to keep me at work.” But after extensive surgeries to the bowel and bladder, which did not heal well, resulting in emergency trips to hospital in an ambulance on more than one occasion, everybody realized her career and her condition were incompatible.

Pearson had bad period pains from the age of 11 but adopted the stoicism of her feisty mother in the north-east of England and suffered in silence. It took 20 years to get a diagnosis. Studying English at Oxford University was tough. “I got together with my ex-husband at university and when we started to have sex, it was incredibly painful. I thought it was all in my head. I thought I need to get over this. I should have gone to get help but I was too embarrassed to see a GP,” she said. She did not go until she started to bleed a lot in her late 20s, by which time she had advanced disease.

Women who are lucky enough to have a primary care doctor who recognizes the symptoms are referred to a gynecologist. The only way to diagnose the disease is through a laparoscopy – keyhole surgery that allows the clinician to view the endometriosis.

But most gynecologists do not have the specialist training to remove the tissue they see, which in severe cases is often very difficult to access. It often involves the bowel or bladder, which are not parts of the body gynecologists usually deal with. Organs can be fused together. Women tell of having hysterectomies and the wholesale removal of ovaries and parts of the bowel and bladder, and yet some diseased tissue remains stuck to nerves and the pain continues.

Yet even the most severe cases can do really well with specialist care, said Hummelshoj, who also runs a global information forum. “Some of them do very well with very good surgery, but unfortunately that surgery is as specialized as cancer surgery.” In fact, she said, cancer surgeons had told her it was more difficult. Women need access to specialist care, not just to a general gynecologist. “We need to train these doctors to deal with endometriosis,” she said.

Geoff Reid in Australia, one of the leading experts, believes the disease may be getting more aggressive. “I have been dealing with endometriosis for 25 years. I just don’t believe that 20 to 25 years ago we were missing the sort of people that we see today,” he said. “I see young women in their early 20s with dreadful colorectal endometriosis and I can’t believe we were missing that. We may have to some extent, but it is my observation over the years that the disease is becoming worse. You see some of the most pitiful people with this disease – it’s awful. People who specialise in endometriosis certainly share that view.”

IVF has meant that women with endometriosis who want children have a good chance of having them. “When we were young we all had relatives who were childless and I’m sure that a lot of them actually had endometriosis-related infertility. Generally speaking we’ve overcome that these days,” said Reid.

But a study in 2008 by the Belgian gynecologist Thomas D’Hooghe suggested that endometriosis may be a huge factor in infertility. D’Hooghe’s team carried out laparoscopies on 221 infertile women who had no obvious symptoms. “These were women who regarded their period pain as being normal and 47% of them had endometriosis and 40% of those had stage three and four disease,” said Reid.

“I find that extraordinary. You can have women with really quite bad endometriosis who are essentially asymptomatic, which means putting a handle on the prevalence of endometriosis very difficult. 10% is the figure that is bandied around. What the true incidence is is really difficult to tell.”

Reid says it is really important that women facing surgery for endometriosis on their ovaries are warned of the danger it could affect their fertility, because it can cause their levels of a critical hormone called AMH to fall by between 50% and 70%. “Perhaps they should consider freezing some embryos or eggs,” he said. If asked, he said, “women almost universally want to do that.”

The care women can get varies massively around the world and within countries, and is often dependent on what they can afford. In the US, insurance companies pay the same amount for any endometriosis surgery, regardless of the method or extent of the disease or the specialization of the doctor.

“You could spend 30 minutes in the operation just burning and zapping and get paid the same amount if you did nine hours doing a meticulous surgery,” said Guidone. “Insurance is not the patient’s friend in this regard.”

That means insurance companies are likely to pay only for a local gynecologist, who may be unable to unwilling to carry out extensive surgery. Nearly every specialist surgeon the Guardian spoke with had stopped accepting private insurance because of low reimbursement rates.

In the UK, a group of doctors who have become highly skilled in advanced keyhole surgical techniques have set up an accreditation process for hospitals where gynecologists are treating endometriosis. So far, 45 centers have been accredited by the British Society for Gynecological Endoscopy.

But patients and some doctors don’t know that high-quality keyhole surgery is available. “If you went up and down the country, you would find a very large number of women who aren’t getting access to this sort of surgery,” said Dominic Byrne, chair of the BSGE’s endometriosis centers and a consultant at the Royal Cornwall Hospitals NHS Trust. “They are told they need an open hysterectomy and their ovaries removed to solve their pain. That would be the most common gynecological answer to severe endometriosis.”

Sometimes women have had their healthy tubes and ovaries removed, only for the gynecologist to reach the cervix and find the endometriosis is too complex for them to deal with, so the diseased tissue is left behind. “That in my opinion is the worst of all worlds. Those patients are quite hard to treat,” said Byrne.

‘The pain is paralyzing’: 30 women describe living with endometriosis

In the developing world, women may get no help at all. “There are a lot of countries that don’t even recognize its existence, especially the Middle Eastern countries,” said Reid.

At the University of Oxford in the UK, researchers are investigating the entire human genome of women with the disease, comparing their genetic makeup with others who do not have it. It is known that about 50% of endometriosis is inherited.

“We need very large numbers of cases and controls, larger than we or any other center could collect alone,” said Krina Zondervan, professor of reproductive and genomic epidemiology. That will have to involve collaboration. The Oxford team, led by Zondervan and consultant gynecologist Prof Christian Becker, have been involved in putting together a global standardization initiative, to ensure researchers around the world now collect compatible data.

But funding is short. Even in the US, less than $1 a year is spent in research per woman who suffers from the disease. In contrast to diabetes, which receives more than $1bn in funding each year from the National Institutes of Health, endometriosis research receives just $7m from the NIH each year. And that is down from $14m in 2011

The Guardian view on endometriosis: a silent source of unnecessary misery

Menstrual Cramps

 Menstrual Cramps 

 Ever think that menstrual cramps are just a fact of life?  That every woman has them?  And even if they don’t, that you are just one of the unlucky ones?   I call BS!  Cramps are actually a symptom of an underlying problem.  They can be cured.  The only thing that is required for that is to look at the underlying causes.  Once those are taken care of, the cramps almost always go away, or at least are eased considerably.

An important side note before getting started is that the same problems that cause cramping are the ones that cause a heavy menstrual flow.  Managing to cure one almost definitely cures the other (presuming that what is being handled is primary dysmenorrhea, not a form of  secondary dysmenorrhea caused by an underlying physiological abnormality).  This would be helpful for a lot of women.  Heavy blood flow reduces iron levels and can make women weak, woozy, and anemic.   What’s worse, a heavy period is arguably the biggest pain in the ass on the planet.

There are three respects in which a natural, paleo approach can ease the pain of and even cure menstrual cramps.  They are curing micronutrient deficiencies, cooling inflammation, and restoring hormonal balance.

Micronutrient deficiencies, cramping, and a Paleo diet

Micronutrient deficiencies are a problem for menstrual cramping because micronutrients are key components in the contraction and relaxation of muscle tissue.  Electrolytes in particular, which would be potassium, calcium, sodium, and magnesium, all have well known muscle-relaxing effects.  In fact, deficiencies in any of these nutrients is the primary cause of muscle cramping elsewhere in the body.   Magnesium especially.   With adequate intake of each of these nutrients, as well as the whole slew of micronutrients and vitamins that are enriched on a paleo diet, the intense pain of abdominal muscle cramping can be eased.

A paleo diet maximizes micronutrient intake by the simple fact of keeping a woman’s diet within the range of whole foods.   This helps first by eliminating sources of empty calories.  Empty calories include all desserts, breads, baked goods, sodas, and wheat products.  They contain almost nothing of nutritional value, except for perhaps some B vitamins and a bit of these micronutrients, but all of these nutrients can be obtained from animal and other plant products in much higher quantities.

Moreover, empty calories, particularly wheat-based calories, have downright negative effects on nutrient absorption.  Wheat foods contain proteins called lectins, which bind with micronutrients strongly enough that they prevent normal digestive chemicals from being able to absorb the micronutrients themselves.   For this reason, empty calorie foods such as bread can actually make an individual’s micronutrients pass right through her.  When a woman replaces these empty, or even micronutrient-stealing calories with vegetables and animal products, she naturally increases her intake of just about every vitamin and mineral.  Foods that are particularly rich in magnesium include nuts, cruciferous vegetables, and halibut.  Foods rich in calcium include sardines, dairy products, cruciferous vegetables, and meats.  Foods richest in potassium are bananas, avocadoes, tomatoes, cruciferous greens, and salmon.    Organic vegetables have higher proportions of nutrients than inorganic ones.

Vitamin E has been shown by itself to reduce the pain of menstrual crampingGood sources of vitamin E are cruciferous vegetables such as spinach, turnip greens, broccoli, and chard, almonds, peppers, asparagus, tomatoes, and carrots.  Vitamin E is also available in high amounts in meat products.  Most importantly for paleo dieters, vitamin E is four times as concentrated in grass fed meats than feed lot meat.

Inflammation, cramping, and a paleo diet

A paleo diet is inherently anti-inflammatory.  Inflammatory agents include gluten, other wheat proteins, sugar, particularly fructose, and omega-6 PUFAs which are found in almost all vegetable oils.   A paleo diet is absent of these.  As a matter of fact, calling a paleo diet an “anti-inflammatory” diet is spot on.  The whole point of adopting a paleo diet is to reduce the inflammation that comes from eating toxins.  Yet the benefit of a paleo diet is not just in toxin removal; it is also in the addition of helpful molecules.  Paleo diets active include anti-inflammatory foods such as grass-fed ruminants, seafood, and vitamin- and anti-oxidant- rich plant products.

Reducing inflammation reduces the body’s hyper-reactivity to uterine physiology.   With a calmed immune system, a woman’s body will not leap into inflammatory hyper-drive.

The most important molecule to focus on in a discussion of muscle contractions and menstruation is prostaglandin.  Prostaglandin is an inflammatory eicosanoid, and it’s responsible for the contraction of muscles around the uterus at the time of menstruation.

The precursor to prostaglandin is arachidonic acid, an omega-6 fatty acid.   Arachidonic acid has positive effects in the body, since the inflammatory process is necessary for homeostasis and maintaining optimal health, but when consumed in excess, it provides ample material for the body to mount inflammatory processes.  Arachidonic acid is found naturally in animal products, particularly meat and egg yolks.  This has caused many conventional nutritionists to demonize meat and egg yolks.  Yet AA is also derived from the consumption of linoleic acid, another fatty acid, and linoleic acid is found in great amounts in soy, corn, and vegetable oils.   A natural level of consumption of AA is optimal, and should be ingested in the natural, animal forms.   With this kind of diet, the ratio of omega 6 fats to omega 3 fats is ~ 3:1 or 2:1, which is considered by most researchers today to be the optimal ratio.   When vegetable oils are regularly consumed, the ratio of omega 6 to omega 3 fats can spike to average American levels, ~ 20:1.  That incites the painful, inflammatory response.  No questions about it.

Hormone balance, estrogen dominance, stress, and a paleo diet

The final and most important piece of the puzzle is hormone balance.  When hormones get out of balance, which is really easy for women today, many things can go wrong.  A woman’s reproductive system is not to be messed with.

What goes wrong with menstrual cramping is that the uterine lining becomes too thick.  With a larger lining, more tissue exists to produce prostaglandin.  Moreover, more tissue needs to be shed, so more and more material needs to be squeezed through a smaller space (women with narrow cervixes are more prone to menstrual cramping).   This also, as I hinted at above, means that the exorcised material will be heavier, and the period will last longer.

Estrogen is responsible for the thickening uterus.  Therefore, estrogen dominance is the primary problem that most women with menstrual cramps suffer from.  Estrogen causes their reproductive organs to go into productive hyper-drive, and their abdominal muscles suffer the results.  If estrogen can be brought back down, a woman’s menstrual problems often cease.

Estrogen dominance is caused primarily by two factors: it is caused 1) by the consumption of phytoestrogens, and 2) it is caused by stress.

Phytoestrogens are naturally occurring plant chemicals that resemble, but are not identical to, a woman’s natural estrogen.  What this means is that phytoestrogens enter a woman’s body through her diet and act as estrogen in her body.  In some ways this phenomenon enhances normal estrogen functioning, and in other ways it inhibits the activity and signalling of true estrogen, since it confuses the body’s normal accounting mechanisms.  With both phytoestrogens and true estrogens in the blood, the reproductive organs and hypothalamic receptors do not know how much estrogen to produce.  Sometimes the pituitary will detect the phytoestrogens in the blood and go ahead and decrease it’s production of estrogen, such that a relative balance between estrogen-like chemicals and the rest of a female’s hormones is maintained in the bloodstream, yet other times the pituitary does not detect the phytoestrogens, and it goes on pumping out as much estrogen as it had previously.  In this case, way too much estrogen is floating around in a woman’s bloodstream, and it’s causing all sort of reproductive havoc.  This results in menstrual cramping.  It is also a factor in PMS, PMDD, mood disorders, endometriosis, uterine fibroids, and breast cancer.

Foods that contain phytoestrogens are legumes, nuts, and seeds.  These should be avoided by all women.   The worst of all of them, however, is soy, and is should be avoided at all costs by all women.  Sometimes soy and other phytoestrogens are recommended to women during menopause to mitigate their symptoms, and this does sometimes help with hot flashes and the like.  However, almost always soy leads to decreased ovulation, irregular menstruation, and impaired fertility.   Phytoestrogens may resemble estrogen, but they are not estrogen, and that confusion has plagued the medical establishment and struggling women alike for decades.

A paleo diet eschews soy, legumes, and goes light on nuts and seeds.  For this reason, it is helpful in restoring hormonal imbalance.  A paleo diet also eliminates the toxins I mentioned above which contribute to systemic inflammation, which in turn can incite estrogen production, so in this way it helps restores balance.  And finally, a paleo diet emphasizes natural, grass-fed animal consumption against feed-lot consumption, which minimizes the amount of foreign hormones and foreign hormone disruptors that are often injected into or fed to feed-lot livestock.

A paleo diet also emphasizes organic vegetables, or at the very least washing and peeling vegetables.  Conventionally-grown vegetables are often coated in fertilizers and such that contain potent endocrine disruptors.  It is important, especially during a person’s developmental years, to be as removed from these toxins as possible.

A second cause of estrogen dominance is stress.  Physiological stress from consumption of modern toxins as well as emotional stress from modern living results in a decrease in progesterone production and an increase in estrogen production.  The term “estrogen dominance” was first coined by Dr. Lee , and what it means is that estrogen is higher than the other hormones in the body.  In his book, he talks mostly about how much faster progesterone production falls off in menopause than estrogen production does (by 120 times!).   Estrogen levels may rise in response to stress, but it’s also important to note that estrogen dominance can also mean that estrogen levels stay the same while progesterone and testosterone levels fall.   The only way to insure that progesterone secretion does not stop is to have the healthiest possible functioning HPA axis.  This means reducing stress, both of the emotional kind and the physiological kind.

This being the case, a paleo diet is the optimal course of action.  It markedly reduces all kinds of stress: it eliminates toxins, for example, but it also restores blood sugar balance by eliminating sugar from the diet, which improves mood, and it optimizes dopamine, serotonin, and GABA functioning, all of which are necessary for being in a good mood and having a healthy HPA axis, too.

A caveat: the female response to stress is complicated, and it does not always result in estrogen dominance.  It can, for example, result instead in adrenal fatigue, or in stress-induced hypothalamic amenorrhea.   In both of these cases, hormonal disruption does not lead to estrogen dominance.  Yet in women with menstrual cramps, it is almost certain that this is the case, since excess estrogen is what causes uterine excess.

As a final note on hormone balance, being overweight contributes to estrogen dominance.    Almost all human cells carry an enzyme called aromatase.  What aromatase does is convert testosterone into estrogen.   This means that if aromatase activity has increased in a woman, her estrogen levels will spike, but her progesterone levels will remain the same.   The reason this happens in overweight women is because aromatase is highly active in fat cells.  Worse than that, however, is the fact that aromatase activity begets more aromatase activity, such that being overweight can create a vicious cycle of fat gain and estrogen production.  Many overweight women exist in a state of constant aromatization and estrogen production.  One way to mitigate this problem is to stop consuming aromatase-exciting foods such as soy, and to instead eat foods such as cruciferous vegetables which activate enzymes in the liver responsible for clearing excess estrogen out of a woman’s body.   Another way to mitigate this problem is with natural, non-restrictive weight loss.  A paleo diet provides just such a template.

Exercise

One final way to restore hormonal balance and alleviate menstrual pain is with exercise.  Exercise boosts serotonin levels, and serotonin helps with the pain response.  Moreover, moderate exercise improves mood and mental clarity, improves glucose sensitivity, and better prepares the body to handle other stressors that come its way.

All that said…

hormone balance takes time.   Sometimes results can be seen immediately, but sometimes the body needs months to heal and to readjust the sensitivity of its hormone receptors.  For this reason, all of these steps help with menstrual pain, but patience and stress-reduction are possibly the most crucial steps of all.